Prime Editing: Making the Move to Prime Time
نویسندگان
چکیده
منابع مشابه
PrimPol—Prime Time to Reprime
The complex molecular machines responsible for genome replication encounter many obstacles during their progression along DNA. Tolerance of these obstructions is critical for efficient and timely genome duplication. In recent years, primase-polymerase (PrimPol) has emerged as a new player involved in maintaining eukaryotic replication fork progression. This versatile replicative enzyme, a membe...
متن کاملJob Scheduling for Prime Time vs. Non-Prime Time
Current job scheduling systems for massively parallel machines and Beowulf-class compute clusters support batch scheduling involving two classes of queues: prime time vs. non-prime time. Jobs running in these queue classes must satisfy different criteria with respect to jobsize, runtime, or other resource needs. These constraints are designed to delay big jobs to non-prime time in order to prov...
متن کاملReady for the Prime Time?
Metabolomics is one of the most rapidly growing areas of contemporary science. Although classic genetics aims to link variations in the DNA sequence directly to distinct phenotypes, “-omic” technologies allow us to shift the focus from the specific gene to the actual effects of the gene itself. Because neither the transcriptional or protein profile can be directly correlated with metabolite con...
متن کاملPrime Time for PRIMES.
“In God we trust, all others bring data.” This pithy quote from Edwards Deming, 1 of the fathers of quality improvement (QI), speaks to the centrality of data and measurement in QI. Early on hospitalists realized that QI in the hospital setting was key to their value proposition and return on investment strategy. However, pediatric hospitalists have long complained about the dearth of nationall...
متن کاملReady for Prime Time
Opening of the voltage-dependent Ca 2 channels permits influx of Ca across the plasma membrane, triggering diverse physiological processes. These channels are widely distributed in the cardiovascular system, constituting the main route for Ca entry essential for excitation and contraction. Ten unique 1 subunits, grouped in 3 families (CaV1, CaV2, and CaV3), that encode the low-voltage– activate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The CRISPR Journal
سال: 2020
ISSN: 2573-1599,2573-1602
DOI: 10.1089/crispr.2020.29105.sas